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About 80% of TTP is brought on by deficient action of ADAMTS13. ADAMTS13 deficiency may be constitutive, due to biallelic ADAMTS13 pathogenic variants; or obtained, due to an inhibitory antibody. Analysis of ADAMTS13 activity is carried out applying exams based upon the aptitude of your protease to cleave normal VWF multimers in vitro (e.A result o